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Linotar Psoriasis Medication
Linotar Gel 1%: Product Profile
Linotar Gel 1%, also known as Exorex Lotion 5% v/w (UK) or Exorex® Gel 1% penetrating emulsion (US), is a highly innovative topical dermatological preparation indicated for the treatment of Psoriasis and Eczema. The active ingredient is distilled coal tar. In addition, Linotar Gel 1% features a sophisticated vehicle consisting of a specific combination of free essential fatty acids. Linotar, as a result, has been successfully applied without most of the burdens that are usually associated with the use of more conventional, coal tar preparations.
Contrary to most traditional coal tar preparations, Linotar Gel 1% produces an extremely rapid and almost complete penetration (1). The excipients have a transdermal carrier function, bringing coal tar much more efficiently through the affected skin. Thanks to this special feature and due to the general physical properties of Linotar, the product does not provoke as much of the yellow staining that is common to coal tar products, nor does it produce the traditional strong coal tar smell: The product "disappears" within minutes.
Linotar has been developed by Meyer Zall Laboratories of South Africa and was first launched in 1993 in its home market, South Africa, for both the indications Psoriasis and Eczema, as part of a complete treatment method.Since 1993, Its equivalent, Exorex®, has been successfully introduced in Australia, New Zealand, and in a number of African and Asian countries, as well as in the U.S.A., Canada, Israel, Ireland and the United Kingdom. In 1996 Exorex® 1% was registered in Austria, Greece, The Netherlands and Luxembourg.
Exorex® 1% has been shown to be clinically and statistically equally effective as the vitamin D derivate calcipotriol (also known as Daivonex®, Dovonex® or Psorcutan® Creme) and superior to any coal tar in the treatment of psoriasis, through objective parameters and in patient preference scores. Results of a recently completed Austrian (University of Vienna, 2001) 40-patient clinical trial proves this point (2). These results closely match those of an earlier 18-patient US pilot study in which Exorex® is compared with the vitamin D derivate Dovonex (calcipotriene) (3).
(1) Saunders James C J, Davis Henry J, Coetzee Linda, Botha Susan; Kruger Ansie E, Grobler, Anne. A Novel Skin Penetration Enhancer: Evaluation By Membrane Diffusion And Confocal Microscopy. J Pharm Pharmaceut Sci (https://www.cspscanada.org/) 2(3):99-107, 1999.
Web link to Exorex / Linotar trans dermal carrier: https://sites.ualberta.ca/~csps/JPPS2(3)/J.Saunders/microscopy.htm
(2) Tzaneva S, Hönigsmann H, Tanew A. Observer-blind, randomized, intrapatient comparison of a novel 1% coal tar preparation (Exorex) and calcipotriol cream in the treatment of plaque type psoriasis. British Journal of Dermatoly 2003 Aug;149(2):350-3.
Web link to Exorex 40-patient clinical study: https://pubmed.ncbi.nlm.nih.gov/12932242/
(3) Veronikis, Irini E, Malabanan, Alan O, Holick Michael F. Comparison of calcipotriene (Dovonex) with a coal tar emulsion (Exorex) in treating psoriasis in adults: a pilot study. Arch Dermatol 1999 Apr;135(4):474-5.
Web link to Exorex 18-patient pilot study: https://pubmed.ncbi.nlm.nih.gov/10206065/
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